Related Clinical and Health Services Research

Within the broad range of clinical and health services research, there are a variety of areas with particular relevance to health technology assessments.

THETA investigators have particular interest in:

• randomized trials to explore the effectiveness of new interventions
• studies of diagnostic accuracy to evaluate the sensitivity, specificity and predictive value of diagnostic tests relative to a gold or reference standard
• studies of prognosis to evaluate outcomes in clinical populations exposed to new drugs or technologies
• administrative data analysis to provide important insights into efficacy, safety profiles and long-term health outcomes of new drugs and technologies, and
• case study research to explore issues such as factors or events influencing health technology assessment decisions.

Grants

Alibhai, Shabbir, Duff Canning S, Fleshner N, Krahn, Murray, Naglie, Gary, Tannock I, Tomlinson, George, Warde P. A 2-year follow-up study of the health effects of androgen deprivation therapy in men with prostate cancer. The National Cancer Institute of Canada $338,946.

Krahn, Murray, Naglie, Gary, Alibhai, Shabbir, Warde P, Tomlinson, George, Laporte, Audrey, Trachtenberg J. Development and applications of the prostate cancer policy model. The National Cancer Institute of Canada: $326,774.

Bell, Chaim. Discontinuity of Chronic Medications in Seniors Surviving ICU Admission: Enhancing Medication Safety. CIHR Operating Grant $52.010.

Bayoumi, Ahmed M., Ray JG. Weighted Study End Points: An Innovative Tool for Assessing Evidence in Therapeutic Trials. Canadian Coordinating Office of Health Technology Assessment $95,910.

Naimark, David M.J., Upshur R, Gilbert B, Goldstein M, Miller J, Mendelsohn D. NephWeb: a web-based, systematic primary-care to nephrology referral and CKD co-management system. A development and evaluation pilot. The Change Foundation of Ontario $200,000.

Urbach, David R., Diamant N, Kortan P, Darling G, Tomlinson, George, Laporte, Audrey, Deitel W. A randomized comparison of laparoscopic myotomy and pneumatic dilatation for achalasia. Canadian Institutes of Health Research (CIHR) Randomized Controlled Trials Grant $445,410.

Urbach, David R., Martin D, Lehoux P, Zlotnick-Shaul R, McKneally, Benstein M. Innovative surgical technologies in Canada: Developing a balanced strategy for integrating new surgical procedures into sustainable health care. Canadian Institutes of Health Research (CIHR) Operating Grant MOP $126,731/2 years.

Alibhai, Shabbir, Krahn, Murray, Naglie, Gary, Tannock I, Duff-Canning S, Ungar, Wendy, Fleshner N. A prospective, longitudinal study to examine health effects of androgen deprivation therapy on older men with prostate cancer. The National Cancer Institute of Canada $441,831.

Coyte, Peter, McKeever P (Co-PIs), Adams A, Chambon A, Dunn JR, Eakin JM, Fernie GR, Flood C, Gignac MA, Gray RE, Harvey ED, Jadad AR, Laporte, Audrey, Laupacis A, Lehoux P, Levinson W, Mackeigan LD. The Interdisciplinary Capacity Enhancement Team for Health Care, Technology and Place (HCT&P). Canadian Institutes of Health Research Interdisciplinary Capacity Enhancement (ICE) Teams Grant Program $1.0 Million.

Coyte, Peter, McKeever P (Co-PIs), Chambon A, Fernie G, Gray R, Harvey ED, Jadad A, Levinson W, O'Brien-Pallas, Smith D, Dunn J, Kearns R, Reid M, Rosenberg M, Carter M, Colantonio A, Dick P, Flood C, Gignac M, Harvey W, Hulchanski D, MacKeigan L, Poland B, Shorter E, Streiner D, Young N. Health Care, Technology, and Place: A Transdisciplinary Research Training Program. Canadian Institutes of Health Research Strategic Training Programs $2.5 Million.

Naimark, David M.J., Bott M, Tobe SW, Sasal J, Reznick RK. Promotion of Urine Microalbuminuria Screening Among Primary Care Physicians: An Educational Intervention Trial. CIHR Rx & D $60,323.

Publications

Fowler, Robert, Sabur N, Juurlink D, Adhikari N, Sibbald WJ, Martin C. Sex-based differences in the delivery and outcomes of critical care. CMAJ 2007 Published Ahead of Print November www.cmaj.ca; :.

Paterson JM, Carney G, Anderson G, Bassett K, Naglie, Gary, Laupacis A for the BC-Ontario Pharmacosurveillance for Decision-making Collaborative. Case selection for statins was similar in two Canadian provinces: BC and Ontario. Journal of Clinical Epidemiology 2007; 60:73-78.

Chon CAKY, Tomlinson, George, Chodirker L, Figdor N, Uster M, Naglie, Gary, Krahn, Murray. An unadjusted NNT was a moderately good predictor of health benefit. J Clin Epidemiol 2006 Mar; 59(3):224-33.

Mamdani, Muhammad, Warren L, Kopp A, Paterson JM, Laupacis A, Bassett K, Anderson GM. Changes in rates of upper gastrointestinal hemorrhage after the introduction of cyclooxygenase-2 inhibitors in British Columbia and Ontario. CMAJ 2006; 175:1535-8.

Park-Wyllie LY, Juurlink DN, Kopp A, Shah BR, Stukel TA, Stumpo C, Dresser L, Low DE, Mamdani, Muhammad. Outpatient gatifloxacin therapy and dysglycemia in older adults. N Engl J Med 2006; 354:1352-61.

Alibhai, Shabbir, Leach M, Tomlinson, George, Krahn, Murray, Fleshner N, Holowaty E, Naglie, Gary. 30-day mortality and major complications after radical prostatectomy: influence of age and comorbidity. Journal of the National Cancer Institute 2005; 97(20):1525-32.

Urbach, David R., Baxter NN. Does it matter what a hospital is "high volume" for? The specificity of hospital volume-outcome associations for surgical procedures: Analysis of administrative data. British Medical Journal 2004; 328:737-40.

Choudhry NK, Stelfox HT, Detsky, Allan. Relationships between authors of clinical practice guidelines and the pharmaceutical industry. JAMA 2002 Feb; 6:287(5):612-617.

Bell, Chaim, Redelmeier DA. The mortality of patients admitted to hospital on weekends compared to weekdays. N Engl J Med 2001; 345:663-8.

Team